Regulation of Endothelial Cell Procoagulant Activity by TMEM16 Scramblases Regulation of Endothelial Cell Procoagulant Activity by TMEM16 Scramblases

Regulation of Endothelial Cell Procoagulant Activity by TMEM16 Scramblases

Activated platelets are thought to provide the majority of procoagulant PS, whose externalization is regulated by the phospholipid scramblase transmembrane protein 16F (TMEM16F). This was one of the goals of the research presented by Alec Schmaier, M.D., Ph.D.
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Platelet Factor 4 (PF4) Enhances In Vitro Neutrophil Extracellular Traps (NET) Capture Of Coronaviruses: Clinical and Therapeutic Implications Platelet Factor 4 (PF4) Enhances In Vitro Neutrophil Extracellular Traps (NET) Capture Of Coronaviruses: Clinical and Therapeutic Implications

Platelet Factor 4 (PF4) Enhances In Vitro Neutrophil Extracellular Traps (NET) Capture Of Coronaviruses: Clinical and Therapeutic Implications

Maki Ishizuka and her group at the Children's Hospital of Philadelphia in Philadelphia had stated that platelet factor 4 (PF4), a platelet-specific chemokine, aggregates NETs, enhancing bacterial capture while protecting NETs from nuclease degradation, thereby limiting NDP release. Her aim was to look further into the effect of PF4 on NET-mediated entrapment of coronaviruses.
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