Molecular basis of vitamin K-driven gamma-carboxylation regulating hemostasis at membrane interface

Weikai Li, Ph.D.
Washington University School of Medicine
St. Louis, MO, U.S.

The vitamin K-driven γ-carboxylation of glutamates in hemostatic proteins promotes their membrane assembly required for hemostasis. Modulating this process underlies widely used therapies for both hemorrhagic and thromboembolic diseases. This presentation highlights the molecular mechanisms by which γ-carboxylase orchestrates multistep, chemically demanding reactions while recognizing diverse protein substrates for processive carboxylation.