Maki Ishizuka and her group at the Children's Hospital of Philadelphia in Philadelphia had stated that platelet factor 4 (PF4), a platelet-specific chemokine, aggregates NETs, enhancing bacterial capture while protecting NETs from nuclease degradation, thereby limiting NDP release. Her aim was to look further into the effect of PF4 on NET-mediated entrapment of coronaviruses.
Manuel Salzmann of the Medical University of Vienna, Division of Cardiology, in Vienna, Austria, presented findings on Sunday, July 18, 2021, around the investigation of thrombosis during a SARS-CoV infection, using murine coronavirus M-CoV, histology, high throughput image analysis, qPCR, and ELISA.
Factor XII (FXII) drives intrinsic coagulation and bradykinin production when blood contacts unnatural surface materials. It was identified as a potential therapeutic target for thrombosis with a desirable safety profile.
The fibrinolytic system, and in particular the protease plasmin, play an important role in the maintenance of vascular patency by dissolving fibrinārich thrombi.