Canonical and non-canonical FXII functions synergistically drive ovarian cancer-associated thrombosis and tumor progression


Dillon Bohinc, B.S.
Case Western Reserve University
Cleveland, OH, U.S.

High-grade serous epithelial ovarian cancer (EOC) is the deadliest gynecologic cancer and is associated with a high incidence of venous thromboembolism (VTE). Dillon Bohinc, B.S., and team aimed at elucidating the role of FXII in ovarian cancer–associated thrombosis and tumor biology. Results demonstrate that canonical FXII activation and zymogen FXII synergistically drive hypercoagulability in ovarian cancer and tumor progression, suggesting that targeting FXII functions has the potential to improve prothrombotic risk and perturb tumor-host interactions suppressing tumorigenesis and metastasis.

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