Fibrinogenγ390-396A protects against high fat diet-induced obesity and MASLD by altering glycine metabolism

Woosuk Steve Hur, Ph.D.
University of North Carolina at Chapel Hill
Chapel Hill, NC, U.S.

Obesity is a risk factor for various diseases. There is an increased deposition of extravascular fibrin(ogen) in obese adipose tissues and liver. Woosuk Steve Hur, Ph.D., discusses the aim of the team to determine the molecular mechanisms by which fibrinogen-macrophage interaction drives diet-induced obesity and metabolic sequelae. The study identifies a positive impact of elevating glycine consumption on the development of HFD-induced metabolic sequelae and coagulation function. A novel mechanism that leads to metabolic changes regulating hemostatic/thrombotic potential are discussed.