ISTH News  33 Total

Miss a Session? Access Most ISTH 2021 Presentations On-Demand

Miss a Session? Access Most ISTH 2021 Presentations On-Demand

If you were unable to attend one of your favorite ISTH 2021 Virtual Congress Sessions, please return to www.isth2021live.org to watch the recording. Sessions will be available on the platform for all registration types through July 25.
Browse the Illustrated State-of-the-Art Capsules in RPTH

Browse the Illustrated State-of-the-Art Capsules in RPTH

The ISTH open access journal, Research and Practice in Thrombosis and Haemostasis (RPTH), invited the ISTH 2021 Virtual Congress State-of-the-Art (SOA) speakers to submit Illustrated Capsules featuring the defining science of their presentation.
ISTH Awards Anthony Hubbard With Roberts Medal for SSC Contributions

ISTH Awards Anthony Hubbard With Roberts Medal for SSC Contributions

The International Society on Thrombosis and Haemostasis (ISTH) has awarded the Harold R. Roberts medal to Anthony R. Hubbard, Ph.D., in recognition of his significant contributions to the Scientific and Standardization Committee (SSC). This award signifies meritorious service to the SSC that goes beyond what is expected and that takes place over a significant period of time.
ISTH Member Barry Coller Awarded the Highest Honor of the Society

ISTH Member Barry Coller Awarded the Highest Honor of the Society

The International Society on Thrombosis and Haemostasis (ISTH) has awarded the Robert P. Grant Medal, the highest honor of the Society, to Barry Coller, M.D., in recognition of his outstanding accomplishments in the field of thrombosis and hemostasis.
ISTH Presents 2021 Esteemed Career Awards

ISTH Presents 2021 Esteemed Career Awards

The ISTH has announced the commendable recipients of the 2021 ISTH Esteemed Career Awards. The Esteemed Career Awards are presented to individuals who, in the opinion of their peers, have made significant contributions to the understanding, treatment and diagnosis, research and education in the thrombosis and hemostasis field.
Plan to Attend Supported Symposia and Product Theater Presentations

Plan to Attend Supported Symposia and Product Theater Presentations

Complementing the exciting and innovative scientific program, ISTH 2021 features supported symposia and presentation theaters showcasing the latest diagnostic and therapeutic advances from our industry partners. Plan to attend these informative and exciting sessions highlighting the newest innovations daily from July 18-21.
Participate in New Project on Procoagulant and Apoptotic Platelets

Participate in New Project on Procoagulant and Apoptotic Platelets

The SSC Subcommittees on Platelet Physiology and Vascular Biology seek participation from experts in procoagulant and/or apoptotic platelets.
Participate in Survey on DOAC Prescribing Patterns

Participate in Survey on DOAC Prescribing Patterns

The SSC Subcommittee on Predictive and Diagnostic Variables in Thrombotic Disease asks for collaboration to help better understand prescribing patterns for DOACs to prevent recurrent thrombosis.
RPTH Award

RPTH Award

The RPTH Editor’s Awards are presented annually to up to three early career investigators who submit exemplary articles as selected by a jury of editors. Recipients of this award receive complimentary registration to the ISTH 2021 Virtual Congress, providing the opportunity to network with other exceptional researchers in thrombosis and hemostasis.
JTH Awards

JTH Awards

The Journal of Thrombosis and Haemostasis (JTH) has selected four early career investigators as the 2021 recipients of the JTH Editor’s Awards. A jury of the Editors-in-Chief and Associate Editors of JTH have chosen from a selection of recently published articles that stood out in their contributions to the field of thrombosis and hemostasis.
First-Time Attendee’s Guide to the ISTH Congress

First-Time Attendee’s Guide to the ISTH Congress

Attending an ISTH Congress for the first time can be an overwhelming experience, particularly if you are attending alone. While many attendees have been to the Congress multiple times, there is a unique group of attendees who are making their first appearance at this year’s Congress.
How Social Media Can Enhance Your Congress Experience

How Social Media Can Enhance Your Congress Experience

Although social media use at conferences has always occurred to some degree, the move to a virtual ISTH 2020 Congress underscored its looming presence in the T&H community.
Emergence of VITT: The Role of Prompt and Intensified Worldwide Research Collaboration

Emergence of VITT: The Role of Prompt and Intensified Worldwide Research Collaboration

The emergence of “vaccine-induced immune thrombotic thrombocytopenia (VITT) has caused huge concerns among physicians, researchers, and the public worldwide. 
The Spark of the Blood and Bone Seminar Series: Conquering Scientific Isolation During COVID-19

The Spark of the Blood and Bone Seminar Series: Conquering Scientific Isolation During COVID-19

The COVID-19 pandemic has challenged our resilience at all levels. Priorities, expectations, and approaches have changed multiple times during the past 18 months. In the midst of this isolation, Kellie R. Machlus, Ph.D., created the global, open-access Blood and Bone Seminar Series, which quickly became a viral sensation among thrombosis and hemostasis researchers.
ISTH Congress Chair Sriram Krishnaswamy Welcomes You to ISTH 2021

ISTH Congress Chair Sriram Krishnaswamy Welcomes You to ISTH 2021

2021 ISTH Congress Chair Sriram Krishnaswamy gives a sneak peek on what to expect at this year's congress.
ISTH Professional Success Stories – How the ISTH Can Help Advance Your Career

ISTH Professional Success Stories – How the ISTH Can Help Advance Your Career

Inspiration is a theme repeated by many leading experts in the field, who credit their engagement with the ISTH as an invaluable asset in advancing their career.
Discover a Showcase of Innovation and Technology in the Virtual Exhibition

Discover a Showcase of Innovation and Technology in the Virtual Exhibition

Don’t miss the ISTH 2021 Virtual Exhibition featuring the latest innovations, products, services and solutions that will help you in your practice. 
ISTH Announces Official ISTH 2021 Virtual Congress Twitter Ambassadors

ISTH Announces Official ISTH 2021 Virtual Congress Twitter Ambassadors

The ISTH announced its official Twitter Ambassadors for the ISTH 2021 Virtual Congress. These esteemed scientific communicators will be tweeting throughout the Congress, highlighting the science presented from July 17-21.
The Next Breakthrough in Precision Medicine: OMICs-Based Approaches and Computational Work

The Next Breakthrough in Precision Medicine: OMICs-Based Approaches and Computational Work

Despite remarkable scientific advances and the plethora of scientific information collected in medicine, specific and targeted therapies remain challenging. The study of most disease processes occurs after manifestation of symptoms, which limits innovation of interventions to halt disease progression.
The Duality of the COVID-19 Pandemic: Working from Home and in the Lab

The Duality of the COVID-19 Pandemic: Working from Home and in the Lab

Since emerging in late 2019, COVID-19 impacted every aspect of life. It drastically changed the way we, as scientists and in general, interact with each other. Some virologists, immunologist and hematologists were considered essential and continued to work. For them, unprecedented circumstances emerged, with a race against time to better understand this new virus and the associated disease.
Sexism in Bleeding Disorders: Reframing the Conversation

Sexism in Bleeding Disorders: Reframing the Conversation

Sexism. The word brings on strong feelings for most people, yet it is a fairly common word to hear in the realm of medicine.
Megakaryocytes: Where Are They Now?

Megakaryocytes: Where Are They Now?

Megakaryocytes (MKs) comprise less than 1% of cells within the bone marrow (BM) but generate more than 1,000,000 platelets per second in healthy individuals.
Flow-Based Assays Offer Alternative to Animal Experiments

Flow-Based Assays Offer Alternative to Animal Experiments

The blood vascular system lined by a monolayer of endothelial cells is constantly under flow conditions. These flow conditions create a physiological shear stress not only on the endothelium but also to the blood cells including immune cells and platelets. 
Finding Love at an ISTH Congress: Cecile Denis and Peter Lenting Remember the Spark That Began Their Relationship

Finding Love at an ISTH Congress: Cecile Denis and Peter Lenting Remember the Spark That Began Their Relationship

The ISTH 1999 Congress in Washington, D.C., marked an ending: the final ISTH event of the millennium. However, for Cecile Denis, Ph.D., and Peter Lenting, Ph.D., the ISTH 1999 Congress marked the beginning: the first meeting that led to a relationship, which has withstood long distances and lasted more than 20 years.    

Download and View the ISTH 2021 Abstracts

Download and View the ISTH 2021 Abstracts

The ISTH 2021 abstracts are now live 
Claim Your Virtual Delegate Bag With Unique Offers and Promotions

Claim Your Virtual Delegate Bag With Unique Offers and Promotions

In lieu of traditional delegate bags, all ISTH 2021 Virtual Congress attendees have access to virtual delegate bags online.
Advancing the 3Rs in Thrombosis Research: Blood-Vessel-on-a-Chip

Advancing the 3Rs in Thrombosis Research: Blood-Vessel-on-a-Chip

Forty percent of cardiovascular-related deaths are attributed to inappropriate platelet activation and thrombotic complications. 

Scientific News  24 Total

Efficacy and Safety of Dabigatran in the Treatment and Secondary Prevention of Venous Thromboembolism in Children with Central Line or Implantable Device–related Thrombosis

Efficacy and Safety of Dabigatran in the Treatment and Secondary Prevention of Venous Thromboembolism in Children with Central Line or Implantable Device–related Thrombosis

On Wednesday, July 21, 2021, Manuela Albisetti, Head of the Hemophilia Center of the University Children’s Hospital in Zurich, Switzerland, presented results from research that looked at the efficacy and safety of dabigatran in treatment and secondary prevention of venous thromboembolism (VTE) in children with central venous catheter (CVC)- or implantable device (ID)-related thrombosis.

The VWF-A1 Domain Binding Aptamer BT200 Prolongs the Half-Lives of Different Factor VIII (FVIII) Products in Patients With Severe Hemophilia A and Increases FVIII Levels in Non-Severe Hemophilia A

The VWF-A1 Domain Binding Aptamer BT200 Prolongs the Half-Lives of Different Factor VIII (FVIII) Products in Patients With Severe Hemophilia A and Increases FVIII Levels in Non-Severe Hemophilia A

Cihan Ay, M.D., of the Medical University of Vienna in Vienna, Austria, presented findings from the late-breaking results of the PEGylated aptamer, BT200, in hemophilia A patients.
Prevention of Thrombocytopenia and Thrombosis in Heparin-Induced Thrombocytopenia (HIT) Using Deglycosylated KKO: A Novel Therapeutic for HIT?

Prevention of Thrombocytopenia and Thrombosis in Heparin-Induced Thrombocytopenia (HIT) Using Deglycosylated KKO: A Novel Therapeutic for HIT?

On Tuesday, July 20, 2021, Amrita Sarkar, Ph.D., of the University of Pennsylvania and Children's Hospital of Philadelphia in Philadelphia presented research about heparin-induced thrombocytopenia (HIT) and a potential new therapeutic.
Oral Pazopanib Results in Durable Hemostasis in Patients with Severe Bleeding and RBC Transfusion-dependent Hereditary Hemorrhagic Telangiectasia

Oral Pazopanib Results in Durable Hemostasis in Patients with Severe Bleeding and RBC Transfusion-dependent Hereditary Hemorrhagic Telangiectasia

On Tuesday, July 20, 2021, Hanny Al-Samkari, M.D., of Massachusetts General Hospital in Boston presented results on oral pazopanib for severe hereditary hemorrhagic telangiectasia (HHT)-associated bleeding.

VEGF and Vascular Permeability

VEGF and Vascular Permeability

To find new drug targets for leakage prevention, Lena Claesson-Welsh and her coworkers have delineated the signaling pathway induced by VEGF.
Nanomedicine Targeting to Activated Neutrophils and Neutrophil-Platelet Complexes Provides Effective Thromboprotection

Nanomedicine Targeting to Activated Neutrophils and Neutrophil-Platelet Complexes Provides Effective Thromboprotection

On Monday, July 19, 2021, Dillon Bohinc of Case Western Reserve University School of Medicine in Cleveland presented results from research aimed at developing a therapeutic strategy that specifically targets activated, pathogenic neutrophil subsets without the ubiquitous inhibition of resting cells.

CRISPR Edited Megakaryocytes for Rapid Screening of Platelet Gene Functions

CRISPR Edited Megakaryocytes for Rapid Screening of Platelet Gene Functions

Emilie Montenont, Ph.D., of The University of Utah commented that the goal of her research was to develop and define the strengths and limitations of a rapid and systematic approach to screen genes for platelet functions in primary megakaryocytes called CRIMSON.

Building a Better NET: Neutrophil Extracellular Trap Stabilization to Enhance Microbe Entrapment

Building a Better NET: Neutrophil Extracellular Trap Stabilization to Enhance Microbe Entrapment

When present in high concentrations, NETs injure the microvasculature and induce organ dysfunction. Recently, NET degradation products (NDPs), including cfDNA, histones, and MPO, have been identified in patients with COVID-19, and higher levels have been associated with increased disease severity.
The Role of Platelet Transfusions to Manage Bleeding: Lessons From Randomized Trials (Including Neonates and Children)

The Role of Platelet Transfusions to Manage Bleeding: Lessons From Randomized Trials (Including Neonates and Children)

Platelet transfusions are the second most commonly administered cellular blood component, after red cells. The focus of much of the research on the appropriate use to date has been in adult patients with hematological cancers, looking at questions of optimal dose or safe platelet count threshold.
Personalized Cancer-Associated Thrombosis Risk Assessment: Integration of Plasma Proteomics, Clinical Characteristics, and Machine Learning

Personalized Cancer-Associated Thrombosis Risk Assessment: Integration of Plasma Proteomics, Clinical Characteristics, and Machine Learning

Numerous studies have established that thrombosis is a common complication for cancer patients.  Unfortunately, a uniform biomarker does not exist and the current risk scoring methods exhibit modest accuracy.  Machine learning may be able to help.

Diagnosing Inherited Platelet Disorders: Immunofluorescence on the Blood Smear in Comparison With Genetic Testing

Diagnosing Inherited Platelet Disorders: Immunofluorescence on the Blood Smear in Comparison With Genetic Testing

On Sunday, July 19, 2021, Carlo Zaninetti of the Institut für Immunologie und Transfusionsmedizin, Universitätsmedizin Greifswald in Germany, presented results on the comparison between immunofluorescence and genetic testing for diagnosing inherited platelet disorders (IPDs).

Platelet microRNAs Inhibit Primary Tumor Growth via Broad Modulation of Tumor Cell mRNA Expression in Ectopic Pancreatic Cancer in Mice

Platelet microRNAs Inhibit Primary Tumor Growth via Broad Modulation of Tumor Cell mRNA Expression in Ectopic Pancreatic Cancer in Mice

On Monday, July 19, 2021, Larry Goldfinger of Thomas Jefferson University in Philadelphia presented follow-up research on the inhibitory role for platelets in solid tumor growth mediated by tumor infiltration of platelet microvesicles (microparticles), which are enriched in platelet-derived microRNAs (miRNAs).

Prevention of Arterial and Venous Vascular Events in Symptomatic Peripheral Arterial Disease Patients After Lower Extremity Revascularization in the VOYAGER PAD Trial: Dual Anticoagulant/Antiplatelet

Prevention of Arterial and Venous Vascular Events in Symptomatic Peripheral Arterial Disease Patients After Lower Extremity Revascularization in the VOYAGER PAD Trial: Dual Anticoagulant/Antiplatelet

On Monday, July 19, 2021, Scott Darrell Berkowitz, M.D., Clinician/Scientist at CPC Clinical Research and Visiting Research Professor of Medicine at the University of Colorado School of Medicine in Aurora, Colorado, presented findings from late-breaking results of an analysis from the VOYAGER PAD trial.
ISTH Registry on Pregnancy and COVID-19 Associated Coagulopathy (COV-PREG-COAG)- First Report

ISTH Registry on Pregnancy and COVID-19 Associated Coagulopathy (COV-PREG-COAG)- First Report

The ISTH Scientific and Standardization Committee for Women’s Health Issues in Thrombosis and Hemostasis developed the International Registry on Pregnancy and COVID-19 Associated Coagulopathy (COV-PREG-COAG) addressing COVID-19 associated coagulopathy (CAC) in pregnancy.
Hemostatic Factors and Tumor Immunity – a Double Edged Sword

Hemostatic Factors and Tumor Immunity – a Double Edged Sword

An impressive and growing body of literature indicates that there is a bidirectional relationship between the immune and hemostatic systems.
Regulation of Endothelial Cell Procoagulant Activity by TMEM16 Scramblases

Regulation of Endothelial Cell Procoagulant Activity by TMEM16 Scramblases

Activated platelets are thought to provide the majority of procoagulant PS, whose externalization is regulated by the phospholipid scramblase transmembrane protein 16F (TMEM16F). This was one of the goals of the research presented by Alec Schmaier, M.D., Ph.D.
¹³C Metabolic Flux Analysis in Resting and Thrombin Activated Platelets

¹³C Metabolic Flux Analysis in Resting and Thrombin Activated Platelets

On Sunday, July 18, 2021, Cara Sake of the Colorado School of Mines presented results from research aimed at generating the first metabolic flux map of resting and thrombin-activated platelets based on intracellular isotope profiling.
Crystal Structure of Factor IXa with an Anticoagulant Aptamer Bound to an Allosteric Site

Crystal Structure of Factor IXa with an Anticoagulant Aptamer Bound to an Allosteric Site

Evidence suggests that DTRI-177 may allosterically modulate IXa function and also possibly interfere with the IXa/VIIIa interaction within intrinsic Xase, but this is still unknown.
Platelet Factor 4 (PF4) Enhances In Vitro Neutrophil Extracellular Traps (NET) Capture Of Coronaviruses: Clinical and Therapeutic Implications

Platelet Factor 4 (PF4) Enhances In Vitro Neutrophil Extracellular Traps (NET) Capture Of Coronaviruses: Clinical and Therapeutic Implications

Maki Ishizuka and her group at the Children's Hospital of Philadelphia in Philadelphia had stated that platelet factor 4 (PF4), a platelet-specific chemokine, aggregates NETs, enhancing bacterial capture while protecting NETs from nuclease degradation, thereby limiting NDP release. Her aim was to look further into the effect of PF4 on NET-mediated entrapment of coronaviruses.
Biphasic Thrombus Development During Coronavirus Infection

Biphasic Thrombus Development During Coronavirus Infection

Manuel Salzmann of the Medical University of Vienna, Division of Cardiology, in Vienna, Austria, presented findings on Sunday, July 18, 2021, around the investigation of thrombosis during a SARS-CoV infection, using murine coronavirus M-CoV, histology, high throughput image analysis, qPCR, and ELISA.
Pathogenic Factor XII Mutations: Form Dertermines Dysfunction

Pathogenic Factor XII Mutations: Form Dertermines Dysfunction

Factor XII (FXII) drives intrinsic coagulation and bradykinin production when blood contacts unnatural surface materials. It was identified as a potential therapeutic target for thrombosis with a desirable safety profile.
Controlled Long-Term Knockdown of Plasminogen in Mice and Dogs Using siRNA: Assessment of Phenotype and Toxicity

Controlled Long-Term Knockdown of Plasminogen in Mice and Dogs Using siRNA: Assessment of Phenotype and Toxicity

The fibrinolytic system, and in particular the protease plasmin, play an important role in the maintenance of vascular patency by dissolving fibrin‐rich thrombi.
Role of DOAC in PAD

Role of DOAC in PAD

Peripheral artery disease (PAD) commonly refers to atherosclerosis of the lower extremities and is associated with atherosclerotic disease in other vascular territories.
Impact of Novel Therapies Around the World

Impact of Novel Therapies Around the World

Currently, prophylaxis is recognized as the standard of care for hemophilia. The development of non-replacement therapies led to a considerable achievement in the management of severe hemophilia patients.

Industry News  8 Total

BioMarin Provides Highlights of 5 Years of Clinical Data from Ongoing Phase 1/2 Study of Valoctocogene Roxaparvovec with the Longest Duration of Clinical Experience for a Gene Therapy in Hemophilia A

BioMarin Pharmaceutical Inc. (NASDAQ: BMRN) announced an update to its previously reported results from an open-label Phase 1/2 study of valoctocogene roxaparvovec, an investigational gene therapy treatment for adults with severe hemophilia A.  The Company plans to share the data during an oral presentation at the upcoming International Society on Thrombosis and Haemostasis (ISTH) 2021 Virtual Congress (July 17-21).

Sobi to present data at the ISTH 2021 within rare haematology diseases

Swedish Orphan Biovitrum AB (publ) (Sobi™) presents data at the virtual ISTH 2021, the 29th Congress of the International Society on Thrombosis and Haemostasis, 17 – 21 July 2021.

Catalyst Biosciences Announces Presentations at the International Society on Thrombosis and Haemostasis

Catalyst Biosciences, Inc. (NASDAQ: CBIO) announced four poster presentations on marzaptacog alfa (activated) (MarzAA) and dalcinanonog alfa (DalcA) at the upcoming International Society on Thrombosis and Haemostatis (ISTH) Virtual Congress being held from July 17-21, 2021.

Roche to present new data at the ISTH 2021 Congress highlighting long-standing commitment to advancing haemophilia A standard of care

Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that new data from its haemophilia A clinical programme will be presented at the virtual International Society on Thrombosis and Haemostasis (ISTH) 2021 Congress, from 17-21 July 2021.

uniQure Announces Presentations at Upcoming International Society on Thrombosis and Haemostasis (ISTH) Virtual Congress

uniQure N.V. announced that eight data presentations, of which three are oral presentations, will be delivered at the International Society on Thrombosis and Haemostasis (ISTH) Virtual Congress being held July 17-21, 2021.

Rallybio Announces Clinical Proof of Concept for RLYB211, an Anti-HPA-1a Antibody for the Prevention of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)

Data to be Presented at the International Society on Thrombosis and Haemostasis (ISTH) 2021 Virtual Congress

BioMarin Announces 12 Presentations at the International Society on Thrombosis and Haemostasis (ISTH) 2021 Virtual Congress

Findings to be Presented from Ongoing Studies of Valoctocogene Roxaparvovec Represent Largest and Longest Development Program for any Gene Therapy in Hemophilia A

Octapharma’s ongoing dedication to improving the lives of people with haemophilia and von Willebrand disease to be showcased at the ISTH 2021 Congress

Octapharma announced that new clinical and scientific findings encompassing their Haematology portfolio, including Nuwiq®, wilate®, octanate® and octanine®F, will be presented at the upcoming International Society on Thrombosis and Haemostasis (ISTH) Virtual Congress, taking place on July 17–21, 2021.